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Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 317-321 doi: 10.1007/s11684-012-0203-9

Abstract:

In order to find out the potential indicators predicting prognosis of malignant gastrointestinal stromaltumors (GISTs) after surgical resection, we collected clinical records of 80 patients with malignantpatients with tumor size≤10 cm and>10 cm were 62.3% and 41.8%, respectively (P = 0.002), Tumorswith mitotic index≤5/50 HPF had a higher 3-year survival rate than tumors with mitotic index>5From the present study, we can conclude that besides tumors size and mitotic index, tumor location and

Keywords： gastrointestinal stromal tumors     surgery     survival    

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Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 87-94 doi: 10.1007/s11684-008-0016-z

Abstract: The biological behavior of gastrointestinal stromal tumors (GISTs) are highly variable.
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A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

Eric C.H. Lai,Kam Man Chung,Stephanie H.Y. Lau,Wan Yee Lau

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 108-111 doi: 10.1007/s11684-014-0344-0

Abstract: a 54-year-old man who developed disseminated intra-abdominal recurrence from a previously resected gastrointestinalstromal tumour (GIST) of the small bowel, and the patient presented with hemoperitoneum.

Keywords： gastrointestinal stromal tumour     hemoperitoneum     small bowel GIST     small bowel neoplasm     imatinib    

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Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 509-517 doi: 10.1007/s11684-017-0554-3

Abstract: outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumorsNon-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy.

Keywords： malignant germ cell tumors     ovarian sex cord-stromal tumors     fertility-sparing surgery     prognosis     fertility    

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Rare tumors: a blue ocean of investigation

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 220-230 doi: 10.1007/s11684-023-0984-z

Abstract: Although rare tumors account for a non-negligible number, the practice of precision medicine and developmentHerein, by reviewing the epidemiological data of Chinese solid tumors and publications defining raretumors in other areas, we proposed a definition of rare tumor in China, including 515 tumor types withLastly, we pinpointed the current recommendation chance for patients with rare tumors to be involved

Keywords： rare tumors     diagnosis flowchart     treatment strategy     clinical trials recommendation    

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Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 20-31 doi: 10.1007/s11684-016-0493-4

Abstract: While traditional serum assays have limited sensitivity and specificity, gastrointestinal juice may provideHerein, the current progress in the relationship between gastrointestinal fluid analyses and GC is systematicallycombination tests of different category markers could provide important diagnostic and prognostic clues for gastrointestinalGastrointestinal fluid examination could also predict the adverse effects of postgastrectomy, such asThe methods for obtaining the samples of gastrointestinal juice with minimum incision should also be

Keywords： gastrointestinal fluid     gastric carcinoma     biomarker     diagnosis     prognosis     gastrectomy     adverse events    

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Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3,   Pages 333-344 doi: 10.1007/s11705-021-2059-5

Abstract: first discusses the temperature-gradient and the spatially-structured immunological landscape in solid tumors

Keywords： nano-enabled hyperthermia     immunogenic cell death     heterogeneous immunological landscape     tumor microenvironment    

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Minimal residual disease in solid tumors: an overview

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 649-674 doi: 10.1007/s11684-023-1018-6

Abstract: residual disease (MRD) is termed as the small numbers of remnant tumor cells in a subset of patients with tumorsand strategies for the detection of cancer, and emphasizes the application of MRD detection in solid tumors

Keywords： MRD     solid tumor     CTC     ctDNA    

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Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status

Chenfei Zhou, Jun Zhang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 12-23 doi: 10.1007/s11684-019-0685-9

Abstract:

Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the lastapproved by the US Food and Drug Administration as the first agent for treatment of metastatic solid tumors

Keywords： gastrointestinal cancer     immune checkpoint inhibitor     combination therapy    

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Gastrointestinal damage caused by swallowing multiple magnets

Shiqi Liu, Jianhui Li, Yi Lv

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 280-287 doi: 10.1007/s11684-012-0207-5

Abstract: Various gastrointestinal damages such as necrosis and intestinal perforation or fistula were encountered

Keywords： magnet     ingestion     fistula     perforation    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: Immunotherapies based on immune checkpoint blockade (ICB) have significantly improved patient outcomes and offered new approaches to cancer therapy over the past decade. To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapy. Blockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers, however, a large subset of refractory patients presents poor responsiveness to ICB therapy; and the underlying mechanism remains elusive. Recently, numerous studies have revealed that metabolic reprogramming of tumor cells restrains immune responses by remodeling the tumor microenvironment (TME) with various products of metabolism, and combination therapies involving metabolic inhibitors and ICIs provide new approaches to cancer therapy. Nevertheless, a systematic summary is lacking regarding the manner by which different targetable metabolic pathways regulate immune checkpoints to overcome ICI resistance. Here, we demonstrate the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting tumor metabolic pathways and immune checkpoints.

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic strategies    

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Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 256-264 doi: 10.1007/s11684-009-0052-3

Abstract: More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologic cancer, especially in ovarian cancer. In this article, we systematically review the current targeted therapeutic trials running in clinic. Large, randomized trials have been conducted in the treatment of ovarian cancer, endometrial cancer and cervical cancer by using small molecule, antisense, mutational gene as well as antibodies. Other planned or ongoing trials currentlytargeted at molecular markers which may play important roles in gynecological carcinogenesis andprogression suggest that combination chemotherapy with molecular targeted therapy will ultimately be an importantoption.

Keywords： target therapy     gynecologic malignant tumors     clinical trail     molecular medicine    

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Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 101-111 doi: 10.1007/s11684-019-0698-4

Abstract: employed two commercial kits to determine MSI and forensic short tandem repeat (STR) alternations in 250 gastrointestinal(GI) tumors.

Keywords： mismatch repair protein deficiency (MMR-D)     microsatellite instability (MSI)     short tandem repeats (STR)     gastrointestinal    

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High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Frontiers of Medicine   Pages 907-923 doi: 10.1007/s11684-023-1009-7

Abstract: The characteristic genetic abnormality of neuroendocrine neoplasms (NENs), a heterogeneous group of tumorsWe tested FAK variants in 157 tumor samples collected from Chinese patients with pancreatic tumorsrepetitive matrix protein 4 (SRRM4) was overexpressed in FAK6/7-positive pancreatic tumorsand breast tumors, which promoted the formation of FAK6/7 in cells.

Keywords： FAK6/7     SRRM4     neuroendocrine neoplasms     pancreas     breast    

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Ingestible wireless capsules for enhanced diagnostic inspection of gastrointestinal tract

Mahdi RASOULI, Andy Prima KENCANA, Van An HUYNH, Eng Kiat TING, Joshua Chong Yue LAI, Kai Juan WONG, Su Lim TAN, Soo Jay PHEE

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 1,   Pages 40-44 doi: 10.1007/s11465-011-0204-4

Abstract:

Wireless capsule endoscopy has become a common procedure for diagnostic inspection of gastrointestinalpropose and develop two wireless endoscopes with maneuverable vision systems to enhance diagnosis of gastrointestinal

Keywords： wireless capsule endoscopy     ingestible medical device     in-body medical device     miniature actuator     medical robot     medical imaging    

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Title Author Date Type Operation

Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors

Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng

Journal Article

Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of

LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei

Journal Article

A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

Eric C.H. Lai,Kam Man Chung,Stephanie H.Y. Lau,Wan Yee Lau

Journal Article

Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Journal Article

Rare tumors: a blue ocean of investigation

Journal Article

Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

Lei Huang,Aman Xu

Journal Article

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

Journal Article

Minimal residual disease in solid tumors: an overview

Journal Article

Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status

Chenfei Zhou, Jun Zhang

Journal Article

Gastrointestinal damage caused by swallowing multiple magnets

Shiqi Liu, Jianhui Li, Yi Lv

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory

Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,

Journal Article

Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Journal Article

High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Journal Article

Ingestible wireless capsules for enhanced diagnostic inspection of gastrointestinal tract

Mahdi RASOULI, Andy Prima KENCANA, Van An HUYNH, Eng Kiat TING, Joshua Chong Yue LAI, Kai Juan WONG, Su Lim TAN, Soo Jay PHEE

Journal Article